Bruce Lin
Research summary:
Heart is one of the major organs that is limited in regeneration; thus far, efforts in regenerative models of the heart are limited to either neonatal or non-mammalian models. In contrast to the classic Mus musculus (Mus) used in laboratories, Acomys (Ac) mice, a species native to northern Africa, have been demonstrated to be hyper-regenerative in multiple organ systems. Pilot studies in Ac ischemic heart injuries have shown that Ac hearts exhibit near absence of pathological remodelling and rescue of cardiac function. I hope to use next-gen sequencing and analysis techniques to uncover the unique cellular dynamics of Ac mice that protects them in ischemic heart injury. Using the results from our analysis we aim to identify novel therapeutic targets for post myocardial infarction (MI) management.
Personal summary:
I graduated from Pharmacology undergraduate degree at UBC, and was captured by the unique physiology and characteristics of the heart. I discovered the promising prospects of regenerative medicine during my studies of Master of Engineering in Biomedical Engineering. Since Joining Dr. Rossi’s lab in 2022, I was able to merge my interest in the heart and regenerative medicine and work on projects that truly inspire me. Outside of the lab I enjoy skiing, weight training, and spending time with my dog.
Heart is one of the major organs that is limited in regeneration; thus far, efforts in regenerative models of the heart are limited to either neonatal or non-mammalian models. In contrast to the classic Mus musculus (Mus) used in laboratories, Acomys (Ac) mice, a species native to northern Africa, have been demonstrated to be hyper-regenerative in multiple organ systems. Pilot studies in Ac ischemic heart injuries have shown that Ac hearts exhibit near absence of pathological remodelling and rescue of cardiac function. I hope to use next-gen sequencing and analysis techniques to uncover the unique cellular dynamics of Ac mice that protects them in ischemic heart injury. Using the results from our analysis we aim to identify novel therapeutic targets for post myocardial infarction (MI) management.
Personal summary:
I graduated from Pharmacology undergraduate degree at UBC, and was captured by the unique physiology and characteristics of the heart. I discovered the promising prospects of regenerative medicine during my studies of Master of Engineering in Biomedical Engineering. Since Joining Dr. Rossi’s lab in 2022, I was able to merge my interest in the heart and regenerative medicine and work on projects that truly inspire me. Outside of the lab I enjoy skiing, weight training, and spending time with my dog.
