Publications:
Activation of β-catenin in mesenchymal progenitors leads to muscle mass loss.
Kajabadi N, Low M, Jacques E, Lad H, Tung LW, Babaeijandaghi F, Gamu D, Zelada D, Wong CK, Chang C, Yi L, Wosczyna MN, Rando TA, Henríquez JP, Gibson WT, Gilbert PM, Rossi FMV. Dev Cell. 2023 Mar 27;58(6):489-505.e7. doi: 10.1016/j.devcel.2023.02.009.
Spatial compartmentalization of signaling imparts source-specific functions on secreted factors.
Groppa E, Martini P, Derakhshan N, Theret M, Ritso M, Tung LW, Wang YX, Soliman H, Hamer MS, Stankiewicz L, Eisner C, Erwan LN, Chang C, Yi L, Yuan JH, Kong S, Weng C, Adams J, Chang L, Peng A, Blau HM, Romualdi C, Rossi FMV. Cell Rep. 2023 Jan 31;42(2):112051. doi: 10.1016/j.celrep.2023.112051. Online ahead of print.
TNFα and IFNγ cooperate for efficient pro- to anti-inflammatory transition of macrophages during muscle regeneration.
Babaeijandaghi F, Paiero A, Long R, Tung LW, Smith SP, Cheng R, Smandych J, Kajabadi N, Chang CK, Ghassemi A, Kennedy WDM, Soliman H, Schutz PW, Rossi FMV. Proc Natl Acad Sci U S A. 2022 Nov;119(44):e2209976119. doi: 10.1073/pnas.2209976119.
Thermoneutral Housing and a Western Diet Combination Exacerbates Dysferlin-Deficient Muscular Dystrophy.
Donen GS, White Z, Sauge E, Ritso M, Theret M, Boyd J, Devlin AM, Rossi FMV, Bernatchez P. Muscle Nerve. 2022 Oct;66(4):513-522. doi: 10.1002/mus.27680.
Metabolic reprogramming of skeletal muscle by resident macrophages points to CSF1R inhibitors as muscular dystrophy therapeutics.
Babaeijandaghi F, Cheng R, Kajabadi N, Soliman H, Chang CK, Smandych J, Tung LW, Long R, Ghassemi A, Rossi FMV. Sci Transl Med. 2022 Jun 29;14(651):eabg7504. doi: 10.1126/scitranslmed.abg7504.
Pleiotropic activation of endothelial function by angiotensin II receptor blockers is crucial to their protective anti-vascular remodeling effects.
Tehrani AY, White Z, Tung LW, Zhao RRY, Milad N, Seidman MA, Sauge E, Theret M, Rossi FMV, Esfandiarei M, van Breemen C, Bernatchez P. Sci Rep. 2022 Jun 13;12(1):9771. doi: 10.1038/s41598-022-13772-3.
Elevated numbers of infiltrating eosinophils accelerate the progression of Duchenne muscular dystrophy pathology in mdx mice.
Theret M, Rempel L, Hashimoto J, Ritso M, Tung LW, Li FF, Messing M, Hughes M, McNagny K, Rossi F. Development. 2022 Apr 15;149(8):dev200112. doi: 10.1242/dev.200112.
Cholesterol absorption blocker ezetimibe prevents muscle wasting in severe dysferlin-deficient and mdx mice.
White Z, Theret M, Milad N, Tung LW, Chen WW, Sirois MG, Rossi F, Bernatchez P. J Cachexia Sarcopenia Muscle. 2022 Feb;13(1):544-560. doi: 10.1002/jcsm.12879.
Emerging skeletal muscle stromal cell diversity: Functional divergence in fibro/adipogenic progenitor and mural cell populations.
Ritso M, Tung LW, Rossi FMV. Exp Cell Res. 2022 Jan 1;410(1):112947. doi: 10.1016/j.yexcr.2021.112947.
Human skeletal muscle CD90+ fibro-adipogenic progenitors are associated with muscle degeneration in type 2 diabetic patients.
Farup J, Just J, de Paoli F, Lin L, Jensen JB, Billeskov T, Roman IS, Cömert C, Møller AB, Madaro L, Groppa E, Fred RG, Kampmann U, Gormsen LC, Pedersen SB, Bross P, Stevnsner T, Eldrup N, Pers TH, Rossi FMV, Puri PL, Jessen N. Cell Metab. 2021 Nov 2;33(11):2201-2214.e11. doi: 10.1016/j.cmet.2021.10.001.
The Effect of Posterior Lumbar Spinal Surgery on Biomechanical Properties of Rat Paraspinal Muscles 13 Weeks After Surgery.
Yamamoto S, Malakoutian M, Theret M, Street J, Rossi F, Brown SHM, Saito M, Oxland TR. Spine (Phila Pa 1976). 2021 Nov 1;46(21):E1125-E1135. doi: 10.1097/BRS.0000000000004036.PMID: 34156788
Multipotent stromal cells: One name, multiple identities.
Soliman H, Theret M, Scott W, Hill L, Underhill TM, Hinz B, Rossi FMV. Cell Stem Cell. 2021 Oct 7;28(10):1690-1707. doi: 10.1016/j.stem.2021.09.001.PMID: 34624231
Fibroblast and Myofibroblast Subtypes: Single Cell Sequencing.
Soliman H, Tung LW, Rossi FMV. Methods Mol Biol. 2021;2299:49-84. doi: 10.1007/978-1-0716-1382-5_4.PMID: 34028734
Macrophages in Skeletal Muscle Dystrophies, An Entangled Partner.
Theret M, Saclier M, Messina G, Rossi FMV. J Neuromuscul Dis. 2022;9(1):1-23. doi: 10.3233/JND-210737.
Larger muscle fibers and fiber bundles manifest smaller elastic modulus in paraspinal muscles of rats and humans.
Malakoutian M, Theret M, Yamamoto S, Dehghan-Hamani I, Lee M, Street J, Rossi F, Brown SHM, Oxland TR. Sci Rep. 2021 Sep 17;11(1):18565. doi: 10.1038/s41598-021-97895-z.PMID: 34535711
In vitro assessment of anti-fibrotic drug activity does not predict in vivo efficacy in murine models of Duchenne muscular dystrophy.
Theret M, Low M, Rempel L, Li FF, Tung LW, Contreras O, Chang CK, Wu A, Soliman H, Rossi FMV. Life Sci. 2021 Aug 15; 279:119482. doi: 10.1016/j.lfs.2021.119482. Epub 2021 Apr 20.PMID: 33891939
Migration of Lung Resident Group 2 Innate Lymphoid Cells Link Allergic Lung Inflammation and Liver Immunity.
Mathä L, Romera-Hernández M, Steer CA, Yin YH, Orangi M, Shim H, Chang C, Rossi FM, Takei F. Front Immunol. 2021 Jul 9;12:679509. doi: 10.3389/fimmu.2021.679509. eCollection 2021.PMID: 34305911
Origins, potency, and heterogeneity of skeletal muscle fibro-adipogenic progenitors-time for new definitions.
Contreras O, Rossi FMV, Theret M. Skelet Muscle. 2021 Jul 1;11(1):16. doi: 10.1186/s13395-021-00265-6.PMID: 34210364
Adipocyte death triggers a pro-inflammatory response and induces metabolic activation of resident macrophages.
Lindhorst A, Raulien N, Wieghofer P, Eilers J, Rossi FMV, Bechmann I, Gericke M. Cell Death Dis. 2021 Jun 5;12(6):579. doi: 10.1038/s41419-021-03872-9.PMID: 34091595
Evolving Roles of Muscle-Resident Fibro-Adipogenic Progenitors in Health, Regeneration, Neuromuscular Disorders, and Aging.
Theret M, Rossi FMV, Contreras O. Front Physiol. 2021 Apr 20;12:673404. doi: 10.3389/fphys.2021.673404. eCollection 2021.PMID: 33959042
Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts during Wound Healing.
Abbasi S, Sinha S, Labit E, Rosin NL, Yoon G, Rahmani W, Jaffer A, Sharma N, Hagner A, Shah P, Arora R, Yoon J, Islam A, Uchida A, Chang CK, Stratton JA, Scott RW, Rossi FMV, Underhill TM, Biernaskie J. Cell Stem Cell. 2021 Mar 4; 28(3):581-583. doi: 10.1016/j.stem.2021.02.004.PMID: 33667362
Mapping the origin and fate of myeloid cells in distinct compartments of the eye by single-cell profiling
Peter Wieghofer Nora Hagemeyer, Roman Sankowski, Anja Schlecht, Ori Staszewski, Lukas Amann, Markus Gruber, Jana Koch, Annika Hausmann, Peipei Zhang, Stefaniya Boneva, Takahiro Masuda, Ingo Hilgendorf, Tobias Goldmann, Chotima Böttcher, Josef Priller, Fabio Mv Rossi, Clemens Lange, Marco Prinz
EMBO J 2021 Mar 15;40(6):e105123. doi: 10.15252/embj.2020105123. Epub 2021 Feb 8.
Systemic hypoxia mimicry enhances axonal regeneration and functional recovery following peripheral nerve injuryBrittney D Smaila , Seth D Holland, Farshad Babaeijandaghi, Holly G Henderson, Fabio M V Rossi, Matt S Ramer
Exp Neurol 2020 Dec; 334:113436. doi: 10.1016/j.expneurol.2020.113436. Epub 2020 Aug 16.
Cardiac fibroblast diversity in health and disease.
Soliman H, Rossi FMV. Matrix Biol. 2020 May 21:S0945-053X(20)30054-8. doi: 10.1016/j.matbio.2020.05.003. Online ahead of print.PMID: 32446910
Towards stem cell therapies for skeletal muscle repair.
Judson RN, Rossi FMV. NPJ Regen Med. 2020 May 11;5:10. doi: 10.1038/s41536-020-0094-3. eCollection 2020.PMID: 32411395
TGF-β-driven downregulation of the Wnt/β-Catenin transcription factor TCF7L2/TCF4 in PDGFRα+ fibroblasts.
Contreras O, Soliman H, Theret M, Rossi FMV, Brandan E. J Cell Sci. 2020 May 20:jcs.242297. doi: 10.1242/jcs.242297. Online ahead of print. PMID: 32434871
Murine Tissue-Resident PDGFRα+ Fibro-Adipogenic Progenitors Spontaneously Acquire Osteogenic Phenotype in an Altered Inflammatory Environment.
Eisner C, Cummings M, Johnston G, Tung LW, Groppa E, Chang C, Rossi FM. J Bone Miner Res. 2020 Apr 6. doi: 10.1002/jbmr.4020. Online ahead of print. PMID: 32251540
Pathogenic Potential of Hic1-Expressing Cardiac Stromal Progenitors.
Soliman H, Paylor B, Scott RW, Lemos DR, Chang C, Arostegui M, Low M, Lee C, Fiore D, Braghetta P, Pospichalova V, Barkauskas CE, Korinek V, Rampazzo A, MacLeod K, Underhill TM, Rossi FMV.
Cell Stem Cell. 2020 Jan 20. pii: S1934-5909(19)30526-0. doi: 10.1016/j.stem.2019.12.008.
Hic1 Defines Quiescent Mesenchymal Progenitor Subpopulations with Distinct Functions and Fates in Skeletal Muscle Regeneration.
Scott RW, Arostegui M, Schweitzer R, Rossi FMV, Underhill TM.
Cell Stem Cell. 2019 Dec 5;25(6):797-813.e9. doi: 10.1016/j.stem.2019.11.004.
Targeting myeloid-derived suppressor cells in combination with primary mammary tumor resection reduces metastatic growth in the lungs.
Bosiljcic M, Cederberg RA, Hamilton MJ, LePard NE, Harbourne BT, Collier JL, Halvorsen EC, Shi R, Franks SE, Kim AY, Banáth JP, Hamer M, Rossi FM, Bennewith KL. Breast Cancer Res. 2019 Sep 5;21(1):103. doi: 10.1186/s13058-019-1189-x.
Cross-talk between TGF-β and PDGFRα signaling pathways regulates the fate of stromal fibro-adipogenic progenitors.
Contreras O, Cruz-Soca M, Theret M, Soliman H, Tung LW, Groppa E, Rossi FM, Brandan E.
J Cell Sci. 2019 Oct 9;132(19). pii: jcs232157. doi: 10.1242/jcs.232157.
The origins and non-canonical functions of macrophages in development and regeneration.
Theret M , Mounier R, Rossi F
Development. 2019 May 2;146(9). pii: dev156000. doi: 10.1242/dev.156000.
Microglia’s heretical self-renewal
http://rdcu.be/J4u3
Fabio Rossi and Coral lewis
Nature Neuroscience news & views, March 2018
Inhibition of Methyltransferase Setd7 Allows the in Vitro Expansion of Myogenic Stem Cells with Improved Therapeutic Potential.
Robert N. Judson, Marco Quarta Menno J. Oudhoff Hesham Soliman Lin Yi Chih Kai Chang Gloria Loi Ryan Vander Werff Alissa Cait Mark Hamer Justin Blonigan Patrick Paine Linda T.N. Doan Elena Groppa WenJun He Le Su Regan H. Zhang
Peter Xu Christine Eisner Marcela Low Ingrid Barta Coral-Ann B. Lewis Colby Zaph Mohammad M. Karimi
Thomas A. Rando Fabio M. Rossi
Cell Stem Cel, January 23rd, 2018l: http://www.cell.com/cell-stem-cell/fulltext/S1934-5909(17)30511-8
Increased non-HDL cholesterol levels cause muscle wasting and ambulatory dysfunction in the mouse model of LGMD2B.
Sellers SL, Milad N, White Z, Pascoe CD, Chan R, Payne GW, Seow CY, Rossi F, Seidman MA, Bernatchez P.
J Lipid Res. 2017 Nov 25. pii: jlr.M079459. doi: 10.1194/jlr.M079459. [Epub ahead of print]
PMID:29175948
Increased plasma lipid levels exacerbate muscle pathology in the mdx mouse model of Duchenne muscular dystrophy.
Milad N, White Z, Tehrani AY, Sellers S, Rossi FMV, Bernatchez P.
Skelet Muscle. 2017 Sep 12
PMID: 28899419
Isolation, Culture, and Differentiation of Fibro/Adipogenic Progenitors (FAPs) from Skeletal Muscle.
Judson RN, Low M, Eisner C, Rossi FM.
Methods Mol Biol. 2017;1668:93-103
PMID: 28842904
A blueprint for the next generation of ELSI research, training, and outreach in regenerative medicine.
Illes J, Sipp D, Kleiderman E, Benjaminy S, Isasi R, Lomax G, Master Z, McCormick J, Ogbogu U, Ravitsky V, Robillard JM, Rossi F, Wilson B, Zarzeczny A.
NPJ Regen Med. 2017 Jul 5;2:21. doi: 10.1038/s41536-017-0026-z. eCollection 2017. Review.
PMID:29302357
Loss of Vascular CD34 Results in Increased Sensitivity to Lung Injury
Lo BC, Gold MJ, Scheer S, Hughes MR, Cait J, Debruin E, Chu FSF, Walker DC, Soliman H, Rossi FM, Blanchet MR, Perona-Wright G, Zaph C, McNagny KM.
Am J Respir Cell Mol Biol. 2017 Jul 6. doi: 10.1165
PMID: 28683207
Bone Marrow-Derived Cell Accumulation in the Spinal Cord Is Independent of Peripheral Mobilization in a Mouse Model of Amyotrophic Lateral Sclerosis.
Peake K, Manning J, Lewis CA, Tran K, Rossi F, Krieger C.
Front Neurol. 2017 Mar 8;8:75.
PMID: 28337172
Fibro/Adipogenic Progenitors (FAPs): Isolation by FACS and Culture.
Low M, Eisner C, Rossi F.
Methods Mol Biol. 2017;1556:179-189
PMID: 28247350
Loss of niche-satellite cell interactions in syndecan-3 null mice alters muscle progenitor cell homeostasis improving muscle regeneration.Pisconti A, Banks GB, Babaeijandaghi F, Betta ND, Rossi FM, Chamberlain JS, Olwin BB.
Skelet Muscle. 2016 Oct 4;6:34.
PMID: 27757223
Pharmacological blockage of fibro/adipogenic progenitor expansion and suppression of regenerative fibrogenesis is associated with impaired skeletal muscle regeneration.
Fiore D, Judson RN, Low M, Lee S, Zhang E, Hopkins C, Xu P, Lenzi A, Rossi FM, Lemos DR.
Stem Cell Res. 2016 Jul;17(1):161-9. doi: 10.1016/j.scr.2016.06.007.
PMID: 27376715
G9a regulates group 2 innate lymphoid cell development by repressing the group 3 innate lymphoid cell program.
Antignano F, Braam M, Hughes MR, Chenery AL, Burrows K, Gold MJ, Oudhoff MJ, Rattray D, Halim TY, Cait A, Takei F, Rossi FM, McNagny KM, Zaph C.
J Exp Med. 2016 Jun 27;213(7):1153-62. doi: 10.1084/jem.20151646.
PMID: 27298444
The lysine methyltransferase Ehmt2/G9a is dispensable for skeletal muscle development and regeneration.
Zhang RH, Judson RN, Liu DY, Kast J, Rossi FM.
Skelet Muscle. 2016 May 27;6:22. doi: 10.1186/s13395-016-0093-7. eCollection 2016.
PMID:27239264
SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling. Oudhoff MJ, Braam MJ, Freeman SA, Wong D, Rattray DG, Wang J, Antignano F, Snyder K, Refaeli I, Hughes MR, McNagny KM, Gold MR, Arrowsmith CH, Sato T, Rossi FM, Tatlock JH, Owen DR, Brown PJ, Zaph C. 2016 Dev Cell 37(1):47-57
PMID:27046831
Origin, fate and dynamics of macrophages at CNS interface.
Tobias Goldmann, Peter Wieghofer, Marta Joana Costa Jordão,
Fabiola Prutek, Nora Hagemeyer, Kathrin Frenzel, Lukas Amann,
Ori Staszewski, Katrin Kierdorf, Martin Krueger, Giuseppe Locatelli, Hannah Hochgarner, Robert Zeiser, Slava Epelman, Frederic Geissmann,
Josef Priller, Fabio Rossi, Ingo Bechmann, Martin Kerschensteiner,
Sten Linnarsson, Steffen Jung, Marco Prinz.
Nature Immunology. 2016, doi: 10.1038/ni.3423 PMID:27135602
Perhexiline maleate enhances antitumor efficacy of cisplatin in neuroblastoma by inducing over-expression of NDM29 ncRNA.
Vella S, Penna I, Longo L, Pioggia G, Garbati P, Florio T, Rossi F, Pagano A
Sci Rep. 2015 Dec 17;5:18144. doi: 10.1038/srep18144.
PMID:26674674
Skeletal muscle-resident MSCs and bone formation.
Lemos DR, Eisner C, Hopkins CI, Rossi FM.
Bone. 2015 Jun 21. pii: S8756-3282(15)00249-5. doi: 10.1016/j.bone.2015.06.013. [Epub ahead of print] Review.
PMID: 26103092
Nilotinib reduces muscle fibrosis in chronic muscle injury by promoting TNF-mediated apoptosis of fibro/adipogenic progenitors
Dario R Lemos, Farshad Babaeijandaghi, Marcela Low, Chih-Kai Chang, Sunny T Lee, Daniela Fiore, Regan-Heng Zhang, Anuradha Natarajan, Sergei A Nedospasov & Fabio M V Rossi.
Nat Med. 2015 Jul;21(7):786-94.
PMID: 26053624
Busulfan as a myelosuppressive agent for generating stable high-level bone marrow chimerism in mice.
Peake K, Manning J, Lewis CA, Barr C, Rossi F, Krieger C.
J Vis Exp. 2015 Apr 1;(98)
PMID: 25867947
Submyeloablative conditioning with busulfan permits bone marrow-derived cell accumulation in a murine model of Alzheimer's disease.
Barr CM, Manning J, Lewis CA, Rossi FM, Krieger C.
Neurosci Lett. 2015 Feb 19;588:196-201
PMID: 25582787
Inflammation in muscle repair, aging, and myopathies.
Bouché M, Muñoz-Cánoves P, Rossi F, Coletti D.
Biomed Res Int. 2014;2014:821950. doi: 10.1155/2014/821950. Epub 2014 Aug 4. No abstract available.
PMID: 25162030 [PubMed - in process] Free Article
The role of microglia in human disease: therapeutic tool or target?
Cartier N, Lewis CA, Zhang R, Rossi FM.
Acta Neuropathol. 2014 Sep;128(3):363-80. doi: 10.1007/s00401-014-1330-y. Epub 2014 Aug 9.
PMID: 25107477 [PubMed - in process] Free PMC Article
(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells.
Barsyte-Lovejoy D, Li F, Oudhoff MJ, Tatlock JH, Dong A, Zeng H, Wu H, Freeman SA, Schapira M, Senisterra GA, Kuznetsova E, Marcellus R, Allali-Hassani A, Kennedy S, Lambert JP, Couzens AL, Aman A, Gingras AC, Al-Awar R, Fish PV, Gerstenberger BS, Roberts L, Benn CL, Grimley RL, Braam MJ, Rossi FM, Sudol M, Brown PJ, Bunnage ME, Owen DR, Zaph C, Vedadi M, Arrowsmith CH.
Proc Natl Acad Sci U S A. 2014 Aug 18. pii: 201407358. [Epub ahead of print]
PMID: 25136132 [PubMed - as supplied by publisher]
Collision or convergence?: Beliefs and politics in neuroscience discovery, ethics, and intervention.
Paylor B, Longstaff H, Rossi F, Illes J.
Trends Neurosci. 2014 Aug;37(8):409-12. doi: 10.1016/j.tins.2014.06.001.
PMID: 25086860 [PubMed - in process]
In vivo characterization of neural crest-derived fibro/adipogenic progenitor cells as a likely cellular substrate for craniofacial fibrofatty infiltrating disorders.
Paylor B, Joe AW, Rossi FM, Lemos DR.
Biochem Biophys Res Commun. 2014 Aug 15;451(1):148-51. doi: 10.1016/j.bbrc.2014.07.089. Epub 2014 Jul 26.
PMID: 25073114 [PubMed - in process]
Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation.
Antignano F, Burrows K, Hughes MR, Han JM, Kron KJ, Penrod NM, Oudhoff MJ, Wang SK, Min PH, Gold MJ, Chenery AL, Braam MJ, Fung TC, Rossi FM, McNagny KM, Arrowsmith CH, Lupien M, Levings MK, Zaph C.
J Clin Invest. 2014 May 1;124(5):1945-55. doi: 10.1172/JCI69592. Epub 2014 Mar 25.
PMID: 24667637 [PubMed - indexed for MEDLINE] Free PMC Article
The methyltransferase G9a regulates HoxA9-dependent transcription in AML.
Lehnertz B, Pabst C, Su L, Miller M, Liu F, Yi L, Zhang R, Krosl J, Yung E, Kirschner J, Rosten P, Underhill TM, Jin J, Hébert J, Sauvageau G, Humphries RK, Rossi FM.
Genes Dev. 2014 Feb 15;28(4):317-27. doi: 10.1101/gad.236794.113.
PMID: 24532712 [PubMed - in process]
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Myelosuppressive conditioning using busulfan enables bone marrow cell accumulation in the spinal cord of a mouse model of amyotrophic lateral sclerosis.
Lewis CA, Manning J, Barr C, Peake K, Humphries RK, Rossi F, Krieger C.
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J Biomater Appl. 2012 Sep 27(3):267-75. doi: 10.1177/0885328211401933. Epub 2011 Sep 16.
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The Neuroinflammatory Response in ALS: The Roles of Microglia and T Cells.
Lewis CA, Manning J, Rossi F, Krieger C.
Neurol Res Int. 2012;2012:803701. doi: 10.1155/2012/803701. Epub 2012 May 15.
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Functionally Convergent White Adipogenic Progenitors of Different Lineages Participate in a Diffused System Supporting Tissue Regeneration.
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Stem Cells. 2012 Mar 13. doi: 10.1002/stem.1082. [Epub ahead of print]
PMID: 22415977 [PubMed - as supplied by publisher]
Deconstruction of the SS18-SSX fusion oncoprotein complex: insights into disease etiology and therapeutics.
Su L, Sampaio AV, Jones KB, Pacheco M, Goytain A, Lin S, Poulin N, Yi L, Rossi FM, Kast J, Capecchi MR, Underhill TM, Nielsen TO.
Cancer Cell. 2012 Mar 20;21(3):333-47. doi: 10.1016/j.ccr.2012.01.010.
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Targeted cell fusion facilitates stable heterokaryon generation in vitro
and in vivo.
Long MA, Rossi FM.
PLoS One. 2011;6(10):e26381. Epub 2011 Oct 24.
CD34 Promotes Satellite Cell Motility and Entry into Proliferation to Facilitate Efficient Skeletal Muscle Regeneration.
Alfaro LA, Dick SA, Siegel AL, Anonuevo AS, McNagny KM, Megeney LA, Cornelison DD, Rossi FM.
Stem Cells. 2011 Dec;29(12):2030-41. doi: 10.1002/stem.759.
p53-dependent transcription and tumor suppression are not affected in Set7/9-deficient mice.
Lehnertz B, Rogalski JC, Schulze FM, Yi L, Lin S, Kast J, Rossi FM.
Mol Cell. 2011 Aug 19;43(4):673-80.
Prolonged self-renewal activity unmasks telomerase control of telomere homeostasis and function of mouse hematopoietic stem cells.
Sekulovic S, Gylfadottir V, Vulto I, Gasparetto M, Even Y, Brookes C, Smith C, Eaves CJ, Lansdorp PM, Rossi FM, Humphries RK.
Blood. 2011 Aug 18;118(7):1766-73. Epub 2011 Jul 5.
Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool.
Ajami B, Bennett JL, Krieger C, McNagny KM, Rossi FM.
Nat Neurosci. 2011 Jul 31;14(9):1142-9. doi: 10.1038/nn.2887.
Lysine methyltransferase G9a is required for de novo DNA methylation and the establishment, but not the maintenance, of proviral silencing.
Leung DC, Dong KB, Maksakova IA, Goyal P, Appanah R, Lee S, Tachibana M, Shinkai Y, Lehnertz B, Mager DL, Rossi F, Lorincz MC.
Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5718-23. Epub 2011 Mar 22.
Purification of progenitors from skeletal muscle.
Yi L, Rossi F.
J Vis Exp. 2011 Mar 16;(49). pii: 2476. doi: 10.3791/2476.
Fibro/adipogenic progenitors: a double-edged sword in skeletal muscle regeneration.
Natarajan A, Lemos DR, Rossi FM.
Cell Cycle. 2010 Jun 1;9(11):2045-6. Epub 2010 Jun 1. No abstract available.
Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis.
Joe AW, Yi L, Natarajan A, Le Grand F, So L, Wang J, Rudnicki MA, Rossi FM.
Nat Cell Biol. 2010 Feb;12(2):153-63. Epub 2010 Jan 17.
Activating and inhibitory functions for the histone lysine methyltransferase G9a in T helper cell differentiation and function.
Lehnertz B, Northrop JP, Antignano F, Burrows K, Hadidi S, Mullaly SC, Rossi FM, Zaph C.
J Exp Med. 2010 May 10;207(5):915-22. Epub 2010 Apr 26.
CD34 mediates intestinal inflammation in Salmonella-infected mice.
Grassl GA, Faustmann M, Gill N, Zbytnuik L, Merkens H, So L, Rossi FM, McNagny KM, Finlay BB.
Cell Microbiol. 2010 Nov;12(11):1562-75. doi: 10.1111/j.1462-5822.2010.01488.x.
Effects of granulocyte-colony stimulating factor on bone marrow-derived progenitor cells in murine cardiac transplantation.
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Gossens K, Naus S, Corbel SY, Lin S, Rossi FM, Kast J, Ziltener HJ.
J Exp Med. 2009 Apr 13;206(4):761-78. Epub 2009 Mar 16.
Depot-specific differences in adipogenic progenitor abundance and proliferative response to high-fat diet.
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Stem Cells. 2009 Oct;27(10):2563-70.
Bone marrow-derived cells in the central nervous system of a mouse model of amyotrophic lateral sclerosis are associated with blood vessels and express CX(3)CR1.
Lewis CA, Solomon JN, Rossi FM, Krieger C.
Glia. 2009 Oct;57(13):1410-9.
The differential in vitro and in vivo responses of bone marrow stromal cells on novel porous gelatin-alginate scaffolds.
Yang C, Frei H, Rossi FM, Burt HM.
J Tissue Eng Regen Med. 2009 Dec;3(8):601-14
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Long MA, Rossi FM.
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Extensive fusion of haematopoietic cells with Purkinje neurons in response to chronic inflammation.
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Nat Cell Biol. 2008 May;10(5):575-83. Epub 2008 Apr 20.
Local self-renewal can sustain CNS microglia maintenance and function throughout adult life.
Ajami B, Bennett JL, Krieger C, Tetzlaff W, Rossi FM.
Nat Neurosci. 2007 Dec;10(12):1538-43. Epub 2007 Nov 18.
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Spatial compartmentalization of signaling imparts source-specific functions on secreted factors.
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TNFα and IFNγ cooperate for efficient pro- to anti-inflammatory transition of macrophages during muscle regeneration.
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Thermoneutral Housing and a Western Diet Combination Exacerbates Dysferlin-Deficient Muscular Dystrophy.
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Metabolic reprogramming of skeletal muscle by resident macrophages points to CSF1R inhibitors as muscular dystrophy therapeutics.
Babaeijandaghi F, Cheng R, Kajabadi N, Soliman H, Chang CK, Smandych J, Tung LW, Long R, Ghassemi A, Rossi FMV. Sci Transl Med. 2022 Jun 29;14(651):eabg7504. doi: 10.1126/scitranslmed.abg7504.
Pleiotropic activation of endothelial function by angiotensin II receptor blockers is crucial to their protective anti-vascular remodeling effects.
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Elevated numbers of infiltrating eosinophils accelerate the progression of Duchenne muscular dystrophy pathology in mdx mice.
Theret M, Rempel L, Hashimoto J, Ritso M, Tung LW, Li FF, Messing M, Hughes M, McNagny K, Rossi F. Development. 2022 Apr 15;149(8):dev200112. doi: 10.1242/dev.200112.
Cholesterol absorption blocker ezetimibe prevents muscle wasting in severe dysferlin-deficient and mdx mice.
White Z, Theret M, Milad N, Tung LW, Chen WW, Sirois MG, Rossi F, Bernatchez P. J Cachexia Sarcopenia Muscle. 2022 Feb;13(1):544-560. doi: 10.1002/jcsm.12879.
Emerging skeletal muscle stromal cell diversity: Functional divergence in fibro/adipogenic progenitor and mural cell populations.
Ritso M, Tung LW, Rossi FMV. Exp Cell Res. 2022 Jan 1;410(1):112947. doi: 10.1016/j.yexcr.2021.112947.
Human skeletal muscle CD90+ fibro-adipogenic progenitors are associated with muscle degeneration in type 2 diabetic patients.
Farup J, Just J, de Paoli F, Lin L, Jensen JB, Billeskov T, Roman IS, Cömert C, Møller AB, Madaro L, Groppa E, Fred RG, Kampmann U, Gormsen LC, Pedersen SB, Bross P, Stevnsner T, Eldrup N, Pers TH, Rossi FMV, Puri PL, Jessen N. Cell Metab. 2021 Nov 2;33(11):2201-2214.e11. doi: 10.1016/j.cmet.2021.10.001.
The Effect of Posterior Lumbar Spinal Surgery on Biomechanical Properties of Rat Paraspinal Muscles 13 Weeks After Surgery.
Yamamoto S, Malakoutian M, Theret M, Street J, Rossi F, Brown SHM, Saito M, Oxland TR. Spine (Phila Pa 1976). 2021 Nov 1;46(21):E1125-E1135. doi: 10.1097/BRS.0000000000004036.PMID: 34156788
Multipotent stromal cells: One name, multiple identities.
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Fibroblast and Myofibroblast Subtypes: Single Cell Sequencing.
Soliman H, Tung LW, Rossi FMV. Methods Mol Biol. 2021;2299:49-84. doi: 10.1007/978-1-0716-1382-5_4.PMID: 34028734
Macrophages in Skeletal Muscle Dystrophies, An Entangled Partner.
Theret M, Saclier M, Messina G, Rossi FMV. J Neuromuscul Dis. 2022;9(1):1-23. doi: 10.3233/JND-210737.
Larger muscle fibers and fiber bundles manifest smaller elastic modulus in paraspinal muscles of rats and humans.
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In vitro assessment of anti-fibrotic drug activity does not predict in vivo efficacy in murine models of Duchenne muscular dystrophy.
Theret M, Low M, Rempel L, Li FF, Tung LW, Contreras O, Chang CK, Wu A, Soliman H, Rossi FMV. Life Sci. 2021 Aug 15; 279:119482. doi: 10.1016/j.lfs.2021.119482. Epub 2021 Apr 20.PMID: 33891939
Migration of Lung Resident Group 2 Innate Lymphoid Cells Link Allergic Lung Inflammation and Liver Immunity.
Mathä L, Romera-Hernández M, Steer CA, Yin YH, Orangi M, Shim H, Chang C, Rossi FM, Takei F. Front Immunol. 2021 Jul 9;12:679509. doi: 10.3389/fimmu.2021.679509. eCollection 2021.PMID: 34305911
Origins, potency, and heterogeneity of skeletal muscle fibro-adipogenic progenitors-time for new definitions.
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Adipocyte death triggers a pro-inflammatory response and induces metabolic activation of resident macrophages.
Lindhorst A, Raulien N, Wieghofer P, Eilers J, Rossi FMV, Bechmann I, Gericke M. Cell Death Dis. 2021 Jun 5;12(6):579. doi: 10.1038/s41419-021-03872-9.PMID: 34091595
Evolving Roles of Muscle-Resident Fibro-Adipogenic Progenitors in Health, Regeneration, Neuromuscular Disorders, and Aging.
Theret M, Rossi FMV, Contreras O. Front Physiol. 2021 Apr 20;12:673404. doi: 10.3389/fphys.2021.673404. eCollection 2021.PMID: 33959042
Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts during Wound Healing.
Abbasi S, Sinha S, Labit E, Rosin NL, Yoon G, Rahmani W, Jaffer A, Sharma N, Hagner A, Shah P, Arora R, Yoon J, Islam A, Uchida A, Chang CK, Stratton JA, Scott RW, Rossi FMV, Underhill TM, Biernaskie J. Cell Stem Cell. 2021 Mar 4; 28(3):581-583. doi: 10.1016/j.stem.2021.02.004.PMID: 33667362
Mapping the origin and fate of myeloid cells in distinct compartments of the eye by single-cell profiling
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EMBO J 2021 Mar 15;40(6):e105123. doi: 10.15252/embj.2020105123. Epub 2021 Feb 8.
Systemic hypoxia mimicry enhances axonal regeneration and functional recovery following peripheral nerve injuryBrittney D Smaila , Seth D Holland, Farshad Babaeijandaghi, Holly G Henderson, Fabio M V Rossi, Matt S Ramer
Exp Neurol 2020 Dec; 334:113436. doi: 10.1016/j.expneurol.2020.113436. Epub 2020 Aug 16.
Cardiac fibroblast diversity in health and disease.
Soliman H, Rossi FMV. Matrix Biol. 2020 May 21:S0945-053X(20)30054-8. doi: 10.1016/j.matbio.2020.05.003. Online ahead of print.PMID: 32446910
Towards stem cell therapies for skeletal muscle repair.
Judson RN, Rossi FMV. NPJ Regen Med. 2020 May 11;5:10. doi: 10.1038/s41536-020-0094-3. eCollection 2020.PMID: 32411395
TGF-β-driven downregulation of the Wnt/β-Catenin transcription factor TCF7L2/TCF4 in PDGFRα+ fibroblasts.
Contreras O, Soliman H, Theret M, Rossi FMV, Brandan E. J Cell Sci. 2020 May 20:jcs.242297. doi: 10.1242/jcs.242297. Online ahead of print. PMID: 32434871
Murine Tissue-Resident PDGFRα+ Fibro-Adipogenic Progenitors Spontaneously Acquire Osteogenic Phenotype in an Altered Inflammatory Environment.
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Pathogenic Potential of Hic1-Expressing Cardiac Stromal Progenitors.
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Cell Stem Cell. 2020 Jan 20. pii: S1934-5909(19)30526-0. doi: 10.1016/j.stem.2019.12.008.
Hic1 Defines Quiescent Mesenchymal Progenitor Subpopulations with Distinct Functions and Fates in Skeletal Muscle Regeneration.
Scott RW, Arostegui M, Schweitzer R, Rossi FMV, Underhill TM.
Cell Stem Cell. 2019 Dec 5;25(6):797-813.e9. doi: 10.1016/j.stem.2019.11.004.
Targeting myeloid-derived suppressor cells in combination with primary mammary tumor resection reduces metastatic growth in the lungs.
Bosiljcic M, Cederberg RA, Hamilton MJ, LePard NE, Harbourne BT, Collier JL, Halvorsen EC, Shi R, Franks SE, Kim AY, Banáth JP, Hamer M, Rossi FM, Bennewith KL. Breast Cancer Res. 2019 Sep 5;21(1):103. doi: 10.1186/s13058-019-1189-x.
Cross-talk between TGF-β and PDGFRα signaling pathways regulates the fate of stromal fibro-adipogenic progenitors.
Contreras O, Cruz-Soca M, Theret M, Soliman H, Tung LW, Groppa E, Rossi FM, Brandan E.
J Cell Sci. 2019 Oct 9;132(19). pii: jcs232157. doi: 10.1242/jcs.232157.
The origins and non-canonical functions of macrophages in development and regeneration.
Theret M , Mounier R, Rossi F
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Microglia’s heretical self-renewal
http://rdcu.be/J4u3
Fabio Rossi and Coral lewis
Nature Neuroscience news & views, March 2018
Inhibition of Methyltransferase Setd7 Allows the in Vitro Expansion of Myogenic Stem Cells with Improved Therapeutic Potential.
Robert N. Judson, Marco Quarta Menno J. Oudhoff Hesham Soliman Lin Yi Chih Kai Chang Gloria Loi Ryan Vander Werff Alissa Cait Mark Hamer Justin Blonigan Patrick Paine Linda T.N. Doan Elena Groppa WenJun He Le Su Regan H. Zhang
Peter Xu Christine Eisner Marcela Low Ingrid Barta Coral-Ann B. Lewis Colby Zaph Mohammad M. Karimi
Thomas A. Rando Fabio M. Rossi
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Increased non-HDL cholesterol levels cause muscle wasting and ambulatory dysfunction in the mouse model of LGMD2B.
Sellers SL, Milad N, White Z, Pascoe CD, Chan R, Payne GW, Seow CY, Rossi F, Seidman MA, Bernatchez P.
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Increased plasma lipid levels exacerbate muscle pathology in the mdx mouse model of Duchenne muscular dystrophy.
Milad N, White Z, Tehrani AY, Sellers S, Rossi FMV, Bernatchez P.
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Isolation, Culture, and Differentiation of Fibro/Adipogenic Progenitors (FAPs) from Skeletal Muscle.
Judson RN, Low M, Eisner C, Rossi FM.
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A blueprint for the next generation of ELSI research, training, and outreach in regenerative medicine.
Illes J, Sipp D, Kleiderman E, Benjaminy S, Isasi R, Lomax G, Master Z, McCormick J, Ogbogu U, Ravitsky V, Robillard JM, Rossi F, Wilson B, Zarzeczny A.
NPJ Regen Med. 2017 Jul 5;2:21. doi: 10.1038/s41536-017-0026-z. eCollection 2017. Review.
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Loss of Vascular CD34 Results in Increased Sensitivity to Lung Injury
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Am J Respir Cell Mol Biol. 2017 Jul 6. doi: 10.1165
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Front Neurol. 2017 Mar 8;8:75.
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Loss of niche-satellite cell interactions in syndecan-3 null mice alters muscle progenitor cell homeostasis improving muscle regeneration.Pisconti A, Banks GB, Babaeijandaghi F, Betta ND, Rossi FM, Chamberlain JS, Olwin BB.
Skelet Muscle. 2016 Oct 4;6:34.
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J Exp Med. 2016 Jun 27;213(7):1153-62. doi: 10.1084/jem.20151646.
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The lysine methyltransferase Ehmt2/G9a is dispensable for skeletal muscle development and regeneration.
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SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling. Oudhoff MJ, Braam MJ, Freeman SA, Wong D, Rattray DG, Wang J, Antignano F, Snyder K, Refaeli I, Hughes MR, McNagny KM, Gold MR, Arrowsmith CH, Sato T, Rossi FM, Tatlock JH, Owen DR, Brown PJ, Zaph C. 2016 Dev Cell 37(1):47-57
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Perhexiline maleate enhances antitumor efficacy of cisplatin in neuroblastoma by inducing over-expression of NDM29 ncRNA.
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Sci Rep. 2015 Dec 17;5:18144. doi: 10.1038/srep18144.
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Nilotinib reduces muscle fibrosis in chronic muscle injury by promoting TNF-mediated apoptosis of fibro/adipogenic progenitors
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J Vis Exp. 2015 Apr 1;(98)
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(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells.
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p53-dependent transcription and tumor suppression are not affected in Set7/9-deficient mice.
Lehnertz B, Rogalski JC, Schulze FM, Yi L, Lin S, Kast J, Rossi FM.
Mol Cell. 2011 Aug 19;43(4):673-80.
Prolonged self-renewal activity unmasks telomerase control of telomere homeostasis and function of mouse hematopoietic stem cells.
Sekulovic S, Gylfadottir V, Vulto I, Gasparetto M, Even Y, Brookes C, Smith C, Eaves CJ, Lansdorp PM, Rossi FM, Humphries RK.
Blood. 2011 Aug 18;118(7):1766-73. Epub 2011 Jul 5.
Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool.
Ajami B, Bennett JL, Krieger C, McNagny KM, Rossi FM.
Nat Neurosci. 2011 Jul 31;14(9):1142-9. doi: 10.1038/nn.2887.
Lysine methyltransferase G9a is required for de novo DNA methylation and the establishment, but not the maintenance, of proviral silencing.
Leung DC, Dong KB, Maksakova IA, Goyal P, Appanah R, Lee S, Tachibana M, Shinkai Y, Lehnertz B, Mager DL, Rossi F, Lorincz MC.
Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5718-23. Epub 2011 Mar 22.
Purification of progenitors from skeletal muscle.
Yi L, Rossi F.
J Vis Exp. 2011 Mar 16;(49). pii: 2476. doi: 10.3791/2476.
Fibro/adipogenic progenitors: a double-edged sword in skeletal muscle regeneration.
Natarajan A, Lemos DR, Rossi FM.
Cell Cycle. 2010 Jun 1;9(11):2045-6. Epub 2010 Jun 1. No abstract available.
Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis.
Joe AW, Yi L, Natarajan A, Le Grand F, So L, Wang J, Rudnicki MA, Rossi FM.
Nat Cell Biol. 2010 Feb;12(2):153-63. Epub 2010 Jan 17.
Activating and inhibitory functions for the histone lysine methyltransferase G9a in T helper cell differentiation and function.
Lehnertz B, Northrop JP, Antignano F, Burrows K, Hadidi S, Mullaly SC, Rossi FM, Zaph C.
J Exp Med. 2010 May 10;207(5):915-22. Epub 2010 Apr 26.
CD34 mediates intestinal inflammation in Salmonella-infected mice.
Grassl GA, Faustmann M, Gill N, Zbytnuik L, Merkens H, So L, Rossi FM, McNagny KM, Finlay BB.
Cell Microbiol. 2010 Nov;12(11):1562-75. doi: 10.1111/j.1462-5822.2010.01488.x.
Effects of granulocyte-colony stimulating factor on bone marrow-derived progenitor cells in murine cardiac transplantation.
Rezai N, Deisher TA, Heine HL, Wang X, Corbel SY, Leung J, Kerjner A, Rossi FM, Podor TJ, McManus BM.
Cardiovasc Pathol. 2010 Jan-Feb;19(1):36-47. Epub 2009 Jan 14. No abstract available.
Thymic progenitor homing and lymphocyte homeostasis are linked via S1P-controlled expression of thymic P-selectin/CCL25.
Gossens K, Naus S, Corbel SY, Lin S, Rossi FM, Kast J, Ziltener HJ.
J Exp Med. 2009 Apr 13;206(4):761-78. Epub 2009 Mar 16.
Depot-specific differences in adipogenic progenitor abundance and proliferative response to high-fat diet.
Joe AW, Yi L, Even Y, Vogl AW, Rossi FM.
Stem Cells. 2009 Oct;27(10):2563-70.
Bone marrow-derived cells in the central nervous system of a mouse model of amyotrophic lateral sclerosis are associated with blood vessels and express CX(3)CR1.
Lewis CA, Solomon JN, Rossi FM, Krieger C.
Glia. 2009 Oct;57(13):1410-9.
The differential in vitro and in vivo responses of bone marrow stromal cells on novel porous gelatin-alginate scaffolds.
Yang C, Frei H, Rossi FM, Burt HM.
J Tissue Eng Regen Med. 2009 Dec;3(8):601-14
Silencing inhibits Cre-mediated recombination of the Z/AP and Z/EG reporters in adult cells.
Long MA, Rossi FM.
PLoS One. 2009;4(5):e5435. Epub 2009 May 5.
Extensive fusion of haematopoietic cells with Purkinje neurons in response to chronic inflammation.
Johansson CB, Youssef S, Koleckar K, Holbrook C, Doyonnas R, Corbel SY, Steinman L, Rossi FM, Blau HM.
Nat Cell Biol. 2008 May;10(5):575-83. Epub 2008 Apr 20.
Local self-renewal can sustain CNS microglia maintenance and function throughout adult life.
Ajami B, Bennett JL, Krieger C, Tetzlaff W, Rossi FM.
Nat Neurosci. 2007 Dec;10(12):1538-43. Epub 2007 Nov 18.
