Marine Theret
Name: Marine Theret
Position: Postdoctoral Research Fellow
Nationality: French
Research Summary:
To ensure successful muscle regeneration after damage, the function of muscle stem cells (MuSCs) needs to be coordinated with multiple other cell types, which is achieved by a complex web of interactions. In particular, macrophages (MPs) act on the proliferation, survival and differentiation of both MuSCs and a second tissue resident cell, the fibro/adipogenic precursor (FAP). Muscle-resident FAPs in turn provide trophic support to MuSCs and influence the function of MPs. Alteration of MPs function or FAPs fate impairs skeletal muscle regeneration and leads to fibro-fatty degeneration, typical of chronic damage such as seen in repeated traumas or in muscular dystrophies. Nevertheless, little is known about the signaling pathways involved in the response of FAPs to inflammatory molecules. Here, I propose to: 1) take advantage of newly developed transgenic tools to alter TGFb signaling in FAPs and 2) investigate the effects that such alteration induces on muscle homeostasis.
Personal Summary:
I am a dynamic person. I like playing sport for fun, travelling to discover new cities, landscapes and people. I enjoy being outside and I can spend lots of time just looking at the ocean.
Selected Publications:
- Juban G, Saclier M, Yacoub-Youssef H, Kernou A, Arnold L, Boisson C, Ben Larbi S, Magnan M, Cuvellier S, Théret M, Petrof BJ, Desguerre I, Gondin J, Mounier R, Chazaud B.- AMPK Activation Regulates LTBP4-Dependent TGF-β1 Secretion by Pro-inflammatory Macrophages and Controls Fibrosis in Duchenne Muscular Dystrophy. Cell Rep. 2018 Nov 20;25(8):2163-2176.e6. doi: 10.1016/j.celrep.2018.10.077.
- Theret M, Gsaier L, Schaffer B, Juban G, Ben Larbi S, Weiss-Gayet M, Bultot L, Collodet C, Foretz M, Desplanches D, Sanz P, Zang Z, Yang L, Vial G, Viollet B, Sakamoto K, Brunet A, Chazaud B, Mounier R. AMPKα1-LDH pathway regulates muscle stem cell self-renewal by controlling metabolic homeostasis. EMBO J 2017. 36(13):1946-1962.
- Gondin R, Theret M*, Duhamel G*, Pegan K, Mathieu JRR, Peyssonnaux C, Cuvellier S, Latroche C, Chazaud B, Bendahan D, Mounier R. Myeloid HIFs are dispensable for resolution of inflammation during skeletal muscle repair. J Immunol. 2015. 194(7):3389-99 *authors contributed equally
- Mounier R, Theret M, Lantier L, Foretz, Viollet B. Expanding roles for AMPK in skeletal muscle plasticity. Trends Endocrinol Metab. 2015 26(6):275-286 (revue)
- Mounier R*, Theret M*, Arnold L, Cuvellier S, Bultot L, Göransson O, Sanz N, Ferry A, Sakamoto K, Foretz M, Viollet B, Chazaud B. AMPKα1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regeneration. Cell Metabolism. 2013 18:251-64 *authors contributed equally
- Lesault PF*, Theret M*, Magnan M, Cuvellier S, Niy Y, Jacques T, Gherardi R, Hittinger L, Chazaud B. Macrophages improve survival, proliferation and migration of engrafted myogenic precursor cells into MDX skeletal muscle. PLoS One. 2012 7:e46698 *authors contributed equally
- Rouger K, Larcher T, Dubreil L, Deschamps JY, Le Guiner C, Jouvion G, Delorme B, Leibeau B, Carlus M, Fornasari B, Theret M, Orlando P, Ledevin M, Zuber C, Leroux I, Deleau S, Guigand L, Testault I, Le Rumer E, Fiszman M, Chérel Y. Systemic delivery of allogenic muscle stem cells induces long-term muscle repair and clinical efficacy in duchenne muscular dystrophy dogs. Am J Pathol. 2011 179:2501-18
Position: Postdoctoral Research Fellow
Nationality: French
Research Summary:
To ensure successful muscle regeneration after damage, the function of muscle stem cells (MuSCs) needs to be coordinated with multiple other cell types, which is achieved by a complex web of interactions. In particular, macrophages (MPs) act on the proliferation, survival and differentiation of both MuSCs and a second tissue resident cell, the fibro/adipogenic precursor (FAP). Muscle-resident FAPs in turn provide trophic support to MuSCs and influence the function of MPs. Alteration of MPs function or FAPs fate impairs skeletal muscle regeneration and leads to fibro-fatty degeneration, typical of chronic damage such as seen in repeated traumas or in muscular dystrophies. Nevertheless, little is known about the signaling pathways involved in the response of FAPs to inflammatory molecules. Here, I propose to: 1) take advantage of newly developed transgenic tools to alter TGFb signaling in FAPs and 2) investigate the effects that such alteration induces on muscle homeostasis.
Personal Summary:
I am a dynamic person. I like playing sport for fun, travelling to discover new cities, landscapes and people. I enjoy being outside and I can spend lots of time just looking at the ocean.
Selected Publications:
- Juban G, Saclier M, Yacoub-Youssef H, Kernou A, Arnold L, Boisson C, Ben Larbi S, Magnan M, Cuvellier S, Théret M, Petrof BJ, Desguerre I, Gondin J, Mounier R, Chazaud B.- AMPK Activation Regulates LTBP4-Dependent TGF-β1 Secretion by Pro-inflammatory Macrophages and Controls Fibrosis in Duchenne Muscular Dystrophy. Cell Rep. 2018 Nov 20;25(8):2163-2176.e6. doi: 10.1016/j.celrep.2018.10.077.
- Theret M, Gsaier L, Schaffer B, Juban G, Ben Larbi S, Weiss-Gayet M, Bultot L, Collodet C, Foretz M, Desplanches D, Sanz P, Zang Z, Yang L, Vial G, Viollet B, Sakamoto K, Brunet A, Chazaud B, Mounier R. AMPKα1-LDH pathway regulates muscle stem cell self-renewal by controlling metabolic homeostasis. EMBO J 2017. 36(13):1946-1962.
- Gondin R, Theret M*, Duhamel G*, Pegan K, Mathieu JRR, Peyssonnaux C, Cuvellier S, Latroche C, Chazaud B, Bendahan D, Mounier R. Myeloid HIFs are dispensable for resolution of inflammation during skeletal muscle repair. J Immunol. 2015. 194(7):3389-99 *authors contributed equally
- Mounier R, Theret M, Lantier L, Foretz, Viollet B. Expanding roles for AMPK in skeletal muscle plasticity. Trends Endocrinol Metab. 2015 26(6):275-286 (revue)
- Mounier R*, Theret M*, Arnold L, Cuvellier S, Bultot L, Göransson O, Sanz N, Ferry A, Sakamoto K, Foretz M, Viollet B, Chazaud B. AMPKα1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regeneration. Cell Metabolism. 2013 18:251-64 *authors contributed equally
- Lesault PF*, Theret M*, Magnan M, Cuvellier S, Niy Y, Jacques T, Gherardi R, Hittinger L, Chazaud B. Macrophages improve survival, proliferation and migration of engrafted myogenic precursor cells into MDX skeletal muscle. PLoS One. 2012 7:e46698 *authors contributed equally
- Rouger K, Larcher T, Dubreil L, Deschamps JY, Le Guiner C, Jouvion G, Delorme B, Leibeau B, Carlus M, Fornasari B, Theret M, Orlando P, Ledevin M, Zuber C, Leroux I, Deleau S, Guigand L, Testault I, Le Rumer E, Fiszman M, Chérel Y. Systemic delivery of allogenic muscle stem cells induces long-term muscle repair and clinical efficacy in duchenne muscular dystrophy dogs. Am J Pathol. 2011 179:2501-18
