Osvaldo Conteras
Name: Osvaldo Contreras
Position: BSc,MSc, PhD student
Birthplace: Santiago, Chile
Nationality: Chilean
Previous or Current Education:
Bachelor in Science, Master in Science, PhD Student. Pontificia Universidad Católica de Chile.
Research Summary:
I studied biology in Chile as an undergraduate student in the lab of Dr. Juan Larrain in Planar Cell Polarity signaling and Developmental Biology. Then, I started my PhD in Enrique Brandan’s Lab with muscle connective tissue progenitor cells and to study their role in muscular dystrophy and muscle tissue fibrosis. I am also interested in cell fate determination and skeletal myogenic differentiation. Recently, I travelled to Vancouver to work at UBC in Fabio Rossi's Lab in a Co-op project involving FAPs (fibro/adipogenic progenitors) biology and the TGF-beta signalling pathway.
Personal Summary:
I love mountains and oceans so deeply. I spent most of my weekends and free time rock climbing and surfing. I like talking with people, reading, eating (yummy), I love spending time with my family and relatives, biking, whatnot. Everything related to Nature and Traveling is more than welcome, and let say that my mom thinks that I am a crazy human being because I never stop.
Selected Publications:
Osvaldo Contreras, Maximiliano Villarreal, Enrique Brandan. Nilotinib impairs skeletal myogenesis by increasing myoblast proliferation. Skeletal Muscle. 2018.
Camilo Riquelme-Guzman*, Osvaldo Contreras*, Enrique Brandan. Expression of CTGF/CCN2 in response to LPA is stimulated by fibrotic extracellular matrix via the integrin/FAK axis. American Journal of Physiology-Cell Physiology. 2018. *Both authors contributed equally.
David Gonzalez, Osvaldo Contreras, Daniela L. Rebolledo, Juan Pablo Espinoza, Brigitte van Zundert, Enrique Brandan. ALS skeletal muscle shows enhanced TGF-β signaling, fibrosis and induction of fibro/adipogenic progenitor markers. PLoS ONE. 2017 12 (5) 1-18. https://doi.org/10.1371/journal.pone.0177649
Osvaldo Contreras, Enrique Brandan. Fibro/adipogenic progenitors safeguard themselves: a novel mechanism to reduce fibrosis is discovered. J. Cell Commun. Signal.2017 (11) 77–78. DOI 10.1007/s12079-016-0372-4
Osvaldo Contreras, Daniela L. Rebolledo, Juan Esteban Oyarzún, Hugo C. Olguín, Enrique Brandan. Connective tissue cells expressing fibro/adipogenic progenitor markers increase under chronic damage: relevance in fibroblast-myofibroblast differentiation and skeletal muscle fibrosis. Cell and Tissue Research. 2016; 364(3):647-60. DOI: 10.1007/s00441-015-2343-0.
Jaime Gutiérrez, Cristian Droppelmann, Osvaldo Contreras, Chiaki Takahashi and Enrique Brandan. RECK-mediated β1-integrin regulation by TGFβ1 is critical for wound contraction in mice. PlosOne. 2015; 10 (8). DOI: 10.1371/journal.pone.0135005
Catalina Cofre, María José Acuña, Osvaldo Contreras, María Gabriela Morales, Cecilia Riquelme, Michael Bader, Robson Santos, Claudio Cabello-Verrugio and Enrique Brandan. Transforming growth factor type-binhibits Mas receptor expression in fibroblasts but not in myoblasts or differentiated myotubes; Relevance to fibrosis associated to muscular dystrophies. Biofactors.2015;41 (2), 111–120,DOI: 10.1002/biof.1208
Noelia Escobedo, Osvaldo Contreras, Rosana Muñoz, Marjorie Farías, Héctor Carrasco, Charlotte Hill, Uyen Tran, Oliver Wessely, Andrew Copp and Juan Larraín. Syndecan 4 interacts genetically with Vangl2 to regulate neural tube closure and planar cell polarity. Development.2013; 140, 3008 - 3017. doi:10.1242/dev.091173.
Noelia Escobedo, Marjorie Farias, Hector Carrasco, Osvaldo Contreras, Uyen Tran, Oliver Wessely, Andrew Copp, Juan Larrain. Role of Syndecan-4 in mouse development. Developmental Biology. 2011; 356 (1) 176-1 http://dx.doi.org/10.1016/j.ydbio.2011.05.654.
Contact: [email protected]
Position: BSc,MSc, PhD student
Birthplace: Santiago, Chile
Nationality: Chilean
Previous or Current Education:
Bachelor in Science, Master in Science, PhD Student. Pontificia Universidad Católica de Chile.
Research Summary:
I studied biology in Chile as an undergraduate student in the lab of Dr. Juan Larrain in Planar Cell Polarity signaling and Developmental Biology. Then, I started my PhD in Enrique Brandan’s Lab with muscle connective tissue progenitor cells and to study their role in muscular dystrophy and muscle tissue fibrosis. I am also interested in cell fate determination and skeletal myogenic differentiation. Recently, I travelled to Vancouver to work at UBC in Fabio Rossi's Lab in a Co-op project involving FAPs (fibro/adipogenic progenitors) biology and the TGF-beta signalling pathway.
Personal Summary:
I love mountains and oceans so deeply. I spent most of my weekends and free time rock climbing and surfing. I like talking with people, reading, eating (yummy), I love spending time with my family and relatives, biking, whatnot. Everything related to Nature and Traveling is more than welcome, and let say that my mom thinks that I am a crazy human being because I never stop.
Selected Publications:
Osvaldo Contreras, Maximiliano Villarreal, Enrique Brandan. Nilotinib impairs skeletal myogenesis by increasing myoblast proliferation. Skeletal Muscle. 2018.
Camilo Riquelme-Guzman*, Osvaldo Contreras*, Enrique Brandan. Expression of CTGF/CCN2 in response to LPA is stimulated by fibrotic extracellular matrix via the integrin/FAK axis. American Journal of Physiology-Cell Physiology. 2018. *Both authors contributed equally.
David Gonzalez, Osvaldo Contreras, Daniela L. Rebolledo, Juan Pablo Espinoza, Brigitte van Zundert, Enrique Brandan. ALS skeletal muscle shows enhanced TGF-β signaling, fibrosis and induction of fibro/adipogenic progenitor markers. PLoS ONE. 2017 12 (5) 1-18. https://doi.org/10.1371/journal.pone.0177649
Osvaldo Contreras, Enrique Brandan. Fibro/adipogenic progenitors safeguard themselves: a novel mechanism to reduce fibrosis is discovered. J. Cell Commun. Signal.2017 (11) 77–78. DOI 10.1007/s12079-016-0372-4
Osvaldo Contreras, Daniela L. Rebolledo, Juan Esteban Oyarzún, Hugo C. Olguín, Enrique Brandan. Connective tissue cells expressing fibro/adipogenic progenitor markers increase under chronic damage: relevance in fibroblast-myofibroblast differentiation and skeletal muscle fibrosis. Cell and Tissue Research. 2016; 364(3):647-60. DOI: 10.1007/s00441-015-2343-0.
Jaime Gutiérrez, Cristian Droppelmann, Osvaldo Contreras, Chiaki Takahashi and Enrique Brandan. RECK-mediated β1-integrin regulation by TGFβ1 is critical for wound contraction in mice. PlosOne. 2015; 10 (8). DOI: 10.1371/journal.pone.0135005
Catalina Cofre, María José Acuña, Osvaldo Contreras, María Gabriela Morales, Cecilia Riquelme, Michael Bader, Robson Santos, Claudio Cabello-Verrugio and Enrique Brandan. Transforming growth factor type-binhibits Mas receptor expression in fibroblasts but not in myoblasts or differentiated myotubes; Relevance to fibrosis associated to muscular dystrophies. Biofactors.2015;41 (2), 111–120,DOI: 10.1002/biof.1208
Noelia Escobedo, Osvaldo Contreras, Rosana Muñoz, Marjorie Farías, Héctor Carrasco, Charlotte Hill, Uyen Tran, Oliver Wessely, Andrew Copp and Juan Larraín. Syndecan 4 interacts genetically with Vangl2 to regulate neural tube closure and planar cell polarity. Development.2013; 140, 3008 - 3017. doi:10.1242/dev.091173.
Noelia Escobedo, Marjorie Farias, Hector Carrasco, Osvaldo Contreras, Uyen Tran, Oliver Wessely, Andrew Copp, Juan Larrain. Role of Syndecan-4 in mouse development. Developmental Biology. 2011; 356 (1) 176-1 http://dx.doi.org/10.1016/j.ydbio.2011.05.654.
Contact: [email protected]
